The specific cause of Parkinson's disease is currently unknown, possibly involving both genetic and environmental factors. Researchers have discovered a link between the gut and the brain, leading to a theory that the gut may be the origin point and root cause for some, if not all, of Parkinson's disease development.
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Parkinson's is a neurodegenerative disease where the nerves affecting the motor systems of the body (like movement) start to degenerate and die. This results in a lack of control, visible as tremors, rigidity, slowness of movement and impaired walking. Additionally there are sleep, emotional and other sensory problems.
Currently, it is known that those with family members affected by Parkinson's are more likely to get Parkinson's themselves. Pesticide use is also linked, where farmers who use heavy amounts and frequently have a higher risk of Parkinson's.
In Parkinson's patients, synuclein molecules warp into different shapes and clump together as fibers. Normally, this doesn't happen, and the molecules and soluble. The fibers, however, are insoluble and stick around.
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Atomic-resolution structure of alpha-synuclein fibrils
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α-Synuclein aggregation
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Ten years ago researchers published a paper about their findings reporting seeing these synuclein fibers in the nerves of the gut during autopsies. This was found in people with and without Parkinson's. This may indicate a trigger to Parkinson's that is created by some microbe or toxin, such as from pesticides.
This theory is backed up by further by more research from 2 years ago, where people reported digestive problems, mainly constipation, that can start up to 10 years before the other more notnicable symptoms of Parkinson's become visible. People also report a loss of smell. The nose, like the gut, is another part of the body where nerve cells are exposed to things coming in from the environment.
Collin Challis and his colleagues at the California Institute of Technology, have now shown that these fibers migrate to the brain. The research was published on December 1st, and shows how important the gut is for brain health.
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A test to inject synuclein fibers into the guts of mice, resulted in the fibers migrating to the brain after 3 weeks. After 2 months, it spread to the areas for controlling movement. The mice where less agile, like Parkinson's sufferers.
It's also previously been shown that Parkinson's patients have a different gut bacterial composition compared to healthy people. Inflammation from the wrong bacteria, toxins, or food, can make synuclein more likely to aggregate. Pesticides in water and food can aggravate this development.
The odd thing I find, is that scientists and companies want to develop drugs, to get the body to deal with the poison... rather than stop using poison in the first place. LOL. It's like Monsanto GMO corn and round up. Don't stop using the poison or toxin... no, instead, make something immune to it! It's not odd though, is it? It's all about the money ... Why stop a problem when you can make money from it.
The drugs being developed are looking to clean up the excessive synuclein fibers or block their future formation. And screening methods are being looked into, like a colonoscopy dual purpose exam to include a search for the fibers.
But still, no one is look at the bigger picture and taking the larger issues public for the public to be aware. We keep going forward in false methodologies for living, and by the time we realize the mistakes, many end up paying a large price for it. It's all a race to maximize profits and grow, "progress", expand, take over, etc.
All problems might start in the gut, as I have often heard some people say. What we put into our body becomes our body. Having an unhealthy gut may be responsible for many neurodegenerative illnesses or other diseases that develop in the body. There is still a lot we don't know, even about our own bodies. To know thyself is an ongoing journey.
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Thank you for your time and attention! I appreciate the knowledge reaching more people. Take care. Peace.
References:
- New evidence suggests Parkinson's might start in the gut, not the brain
- Parkinson's disease
- Parkinson’s disease may start in the gut and travel to the brain
- Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
- Colonic bacterial composition in Parkinson's disease
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
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2016-12-07, 5pm